Reference Intervals (RIs), Normal Values, Health Status and Clinical Decision Limits (CDLs), the Theory and the Practice

There was a clear distinction between healthy reference values measured in healthy populations or individuals and patient reference values measured in patients having various diseases. It is now commonly accepted that reference values describe fluctuations observed in healthy populations or individuals, which makes the definition of health or characterization of health status a critical step.

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https://lupinepublishers.com/clinical-community-medicine/fulltext/reference-intervals-ris-normal-values-health-status-and-clinical-decision-limits.ID.000133.php

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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=vfbCW-wAAAAJ&cstart=20&pagesize=80&citation_for_view=vfbCW-wAAAAJ:_axFR9aDTf0C

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